Top About PrecisionJournal Secrets
Top About PrecisionJournal Secrets
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We encourage authors to deposit the action-by-phase protocols applied inside their review in , an open up repository of scientific protocols. Protocols deposited with the authors might be linked to the online Approaches part on publication.
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Reporting studies with more than needed precisions could be misleading (five,6). The quantity of decimal places to become described for the mean, SD, median, and IQR in scientific stories shouldn't exceed that of the precision from the measurement within the raw information.
Knowledge sharing is just not relevant to this article as no datasets were generated or analysed during The existing examine.
Clonal heterogeneity inside tumors is really a roadblock to precision oncology, as dealing with the dominant clone could perhaps spur the growth of a resistant subclone. Griffith et al tracked tumor evolution and refined the clonal architecture of acute myeloid leukemia more than somewhere around 500 days inside of a one individual (taken care of having an induction chemotherapy and 4 rounds of consolidation chemotherapy) to show that: one) all clonal populations originated from clones current just before therapy and no new subclones emerged adhering to treatment method and a couple of) dominant TP53
Supplementary Data is just not edited, typeset or proofed, so authors should make sure it really is Evidently and succinctly presented at First submission, and which the fashion and terminology conform to the remainder of the paper.
Authors really should supply a cover letter that includes the affiliation and contact data to the corresponding writer. The duvet letter is a superb possibility to briefly discuss the context and importance on the submitted function and why it is appropriate for the journal. Be sure to steer clear of repeating information and facts that is certainly already present while in the summary and introduction. The cover letter is just not shared With all the referees, and will be utilised to deliver confidential details, including conflicts of desire, also to declare any associated perform that is certainly in press or submitted elsewhere.
Omics technologies has aided in exploring omics-primarily based biomarkers with Improved precision. The definition of biomarker is often translated in context of omics knowledge by analyzing the Affiliation of your capabilities in the omics profile or signature with specific healthcare problems and setting up computational models While using the attributes selected.
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The info that help the results of this study can be obtained from [3rd party title] but constraints utilize to The provision of those facts, which ended up used beneath licence for The existing review, and so will not be publicly readily available.
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four). Clinically relevant mutations had been found in twenty–forty nine% of breast invasive carcinoma, ovarian substantial-grade serous carcinoma, uterine endometrial, sarcoma, mesothelioma, bladder urothelial carcinoma and lung squamous mobile carcinoma instances, while in other most cancers varieties for example pancreatic, prostate, esophageal and abdomen adenocarcinomas, under 20% of instances possessed mutations in genes existing inside the NGTDC (Fig. 4). We note the scientific actionability of these mutations is going to be depending on the individual situation and scientific instances, like the phase on the tumor and related comorbidities in the participant. This highlights the necessity for About PrecisionJournal scientific interpretation and discussion in which clinically appropriate in a GTAB.
Please post tables at the end of your text doc (in Word or TeX/LaTeX, as correct). Tables which include statistical Evaluation of knowledge really should describe their criteria of error Investigation and ranges in a table legend.